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KMID : 1098420070150020089
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 2 p.89 ~ p.94
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High Throughput Screening on Angiogenesis Inhibitor and Promoter of Medicinal Plants using a Protein Microarray Chip
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In Dong-Soo
Bang Kyung-Hwan
Hyun Dong-Yun
Cha Seon-Woo
Shin Yoo-Soo
Kang In-Cheol
Seong Nak-Sul
Lee Min-Soo
Kim Ok-Tae
Ahn Young-Sub
Kim Eung-Youn
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Abstract
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The effects of angiogenesis inhibitor from the extract libraries of Korean and Chinese medicinal plants were investigated using a protein microarray chip. Protein chip was constructed by immobilization of integrin on protein chip base plates and employed far screening active extracts that inhibit the integrin-fibronectin interaction from the extract libraries. The 100 extracts of medicinal plants were obtained from extract bank of National Institute of Crop Science, RDA. The 14 extracts among 100 extract libraries were shown efficient inhibition activity for the interaction between integrin-fibronectin. The medicinal plants of 14 extracts were Vitex negundo var. incisa (Lam.) C.B. Clarke, Epimedium koreanum Nakai, Cedrela sinensis A. Juss, Ipomea aquatica Forsk, Schisandra chinensis Baill, Pulsatilla koreana Nakai, Paeonia lactiflora Pall. var.hortensis Makino, Oenothera odorata, Allium chinense, Allium victorialis var. platyphyllum MAKINO, Polygonatum odoratum Druce var. pluriflorum Ohwi, Hosta lancifolia, Agrimonia pilosa L. var. japonica Nakai and Potentilla chinensis SER. The Paeonia lactiflora, Oenothera, and Agrimonia pilosa from these 14 extracts libraries were shown strong inhibition activity of integrin .
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KEYWORD
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Angiogenesis, Extract Bank, ProteoChip, Protein Microarray Chip
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